PC Version Edit
Mikiko and Superfly appear as sidekicks in the PC version, and become AI controlled companions as they are rescued. As sidekicks, they will fire upon enemies and react to the player's commands, such as back off, and come. The player can ask the companion to get a pickup, and the companion will obtain it. Obtaining a weapon pickup will make the sidekick use it, and obtaining an ammo pickup will make the sidekick get ammo for the weapon. The sidekick will also get health and armor pickups if asked. Sidekicks cannot use interactables, such as berries and Hosportals. Sidekicks will also sometimes decline getting a pickup, for example, if the pickup is unreachable, if asked to get a health pickup at high health, and certain other situations.
You will need all active sidekicks right beside you so you can proceed past area transitions.
To see more info about their behavior, see Sidekick AI.