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The Mutagenic Marburg Pox Filovirus is deadly infectious disease that by 2455 had wiped out two-thirds of the worlds population.

Tatsuo Ebihara, an ancestor of Toshiro Ebihara and Mikiko Ebihara had developed the cure, but it was stolen by Kage Mishima with the time-traveling powers of the Daikatana, who monopolized and made money off of selling the vaccines, ensuring his allies were alive, and his foes were not.